Hydrazine → 3-Bromo-4-chlorobenzhydrazide
반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[Cl:12])[C:5](OC)=[O:6].[NH2:13][NH2:14]>CO>[Br:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[Cl:12])[C:5]([NH:13][NH2:14])=[O:6]참가 물질
4
반응 조건
- 온도
- 70 °C
실험 절차
Methyl 3-bromo-4-chlorobenzoate (120 mg, 0.481 mmol) was added to hydrazine (23.12 mg, 0.721 mmol) in methanol (8 mL) and refluxed for 12 h at 70° C. Reaction was monitored by TLC. After completion of the reaction, the solvent was removed by vacuum and then compound was purified by column chromatography affording the title compound (30 mg). 1H NMR (400 MHz, CDCl3): δ 8.02 (d, 1H, J=1.6 Hz), 7.60 (dd, 1H, J=2.0 & 8.0 Hz), 7.52 (d, 1H, J=8.0 Hz), ESI-MS: 250.9 [M+H]+.
후처리
- customReaction
- customAfter completion of the reaction
- customthe solvent was removed by vacuum
- customcompound was purified by column chromatography
출처 및 근거
- ORD 기록
- ord-9b1e46968d694f988be8325407bdd3ba
- 출처 데이터셋
- uspto-grants-2015_03
- 특허 번호
- US08987335B2
반응 노트
불러오는 중…