Methanol → Methyl 5-chloropyridine-3-carboxylate

HRID 877615노트

반응식

HRID 877615 반응식
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].S(=O)(=O)(O)O.[CH3:16]O>>[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([O:9][CH3:16])=[O:8]

참가 물질

4

반응물 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 2479865-Chloronicotinic acid

생성물 1

HCID 15421663Methyl 5-chloropyridine-3-carboxylate

실험 절차

5-Chloronicotinic acid (200 mg, 1.269 mmol) was refluxed overnight in the presence of concentrated sulfuric acid (8.20 mg, 0.063 mmol) in methanol (10 mL) at 70° C. The reaction was monitored by TLC. After completion of the reaction, the solvent was removed by vacuum and the compound was purified by column chromatography affording the title compound (120 mg). 1H NMR (400 MHz, CDCl3): δ 9.07 (d, 1H, J=1.6 Hz), 8.72 (d, 1H, J=2.0 Hz), 8.26 (m, 1H), 3.95 (s, 1H).

후처리

  1. customAfter completion of the reaction
  2. customthe solvent was removed by vacuum
  3. customthe compound was purified by column chromatography

출처 및 근거

ORD 기록
ord-42809225335142fc9e035820c45dcc12
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987335B2

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