Methyl formate → Glycine, N-formyl-, ethyl ester

HRID 877656

반응식

HRID 877656 반응식
Cl.[CH2:2]([O:4][C:5](=[O:8])[CH2:6][NH2:7])[CH3:3].[CH:9](OC)=[O:10]>C(N(CC)CC)C>[CH:9]([NH:7][CH2:6][C:5]([O:4][CH2:2][CH3:3])=[O:8])=[O:10]

참가 물질

4

반응물 2

HCID 7865Methyl formateHCID 2723640Glycine ethyl ester, hydrochloride

생성물 1

HCID 76615Glycine, N-formyl-, ethyl ester수율 93%

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

To a 5 L three neck round bottom flask equipped with a mechanic stirrer, a pressure-equalizing funnel and a condenser bearing a calcium chloride drying tube was added glycine ethyl ester hydrochloride (500 g, 3.583 mol) and methyl formate (1.8 L). The suspension was brought to reflux and triethylamine (556 mL) was added to the reaction. The reaction was stirred and refluxed overnight. The reaction was cooled to room temperature and filtered through a Buchner funnel to remove triethylamine hydrochloride salt. The filtrate was concentrated and dried over high vacuum to yield 320 g (93%) of the title compound.

후처리

  1. temperatureto reflux
  2. temperaturerefluxed overnight
  3. filtrationfiltered through a Buchner funnel
  4. customto remove triethylamine hydrochloride salt
  5. concentrationThe filtrate was concentrated
  6. customdried over high vacuum

출처 및 근거

ORD 기록
ord-a65f2f54fff342d3966946a9c29b79b0
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987268B2

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