Potassium Carbonate → methyl 2-((4R,6S)-6-(hydroxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

HRID 877943노트

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HRID 877943 반응식
C([O:4][CH2:5][C@H:6]1[O:11][C:10]([CH3:13])([CH3:12])[O:9][C@@H:8]([CH2:14][C:15]([O:17][CH2:18]C)=[O:16])[CH2:7]1)(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO>[OH:4][CH2:5][C@H:6]1[O:11][C:10]([CH3:12])([CH3:13])[O:9][C@@H:8]([CH2:14][C:15]([O:17][CH3:18])=[O:16])[CH2:7]1

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 53339171ethyl 2-((4R,6S)-6-(acetoxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

생성물 1

HCID 10560752methyl 2-((4R,6S)-6-(hydroxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

시약·촉매·용매 1

HCID 887Methanol용매

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온도
5 °C

실험 절차

Mixture of ethyl 2-((4R,6S)-6-(acetoxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate (80 grams), potassium carbonate (21 grams) in methanol (400 ml) was stirred for 2 hours at 0-10° C. The reaction mixture was quenched with water and then the reaction mixture extracted into methylene chloride and washed it with water. The methylene chloride from the reaction mixture was distilled off under reduced pressure to get the title compound.

후처리

  1. customThe reaction mixture was quenched with water
  2. extractionthe reaction mixture extracted into methylene chloride
  3. washwashed it with water
  4. distillationThe methylene chloride from the reaction mixture was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-479700964776427eaf2efd9b91fe2042
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987444B2

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