Butylamine → N-butyl-2-((4R,6S)-6-(hydroxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetamide

HRID 877949노트

반응식

HRID 877949 반응식
[OH:1][CH2:2][C@H:3]1[O:8][C:7]([CH3:10])([CH3:9])[O:6][C@@H:5]([CH2:11][C:12]([O:14]C)=O)[CH2:4]1.[CH2:16]([NH2:20])[CH2:17][CH2:18][CH3:19]>>[CH2:16]([NH:20][C:12](=[O:14])[CH2:11][C@H:5]1[CH2:4][C@@H:3]([CH2:2][OH:1])[O:8][C:7]([CH3:9])([CH3:10])[O:6]1)[CH2:17][CH2:18][CH3:19]

참가 물질

3

반응물 2

HCID 8007ButylamineHCID 10560752methyl 2-((4R,6S)-6-(hydroxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

생성물 1

HCID 53339170N-butyl-2-((4R,6S)-6-(hydroxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetamide

실험 절차

A mixture of methyl 2-((4R,6S)-6-(hydroxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate (110 grams) and n-butylamine (370 grams) was heated to reflux and stirred. After completion of the reaction, the reaction mixture was distilled under reduced pressure. Water (500 ml) was added to the obtained residue followed by sodium bicarbonate and washed it with petroleum ether. The reaction mixture was extracted into methylene chloride. The solvent from the reaction mixture was distilled off under reduced pressure to get the title compound.

후처리

  1. temperaturewas heated
  2. temperatureto reflux
  3. customAfter completion of the reaction
  4. distillationthe reaction mixture was distilled under reduced pressure
  5. additionWater (500 ml) was added to the obtained residue
  6. washwashed it with petroleum ether
  7. extractionThe reaction mixture was extracted into methylene chloride
  8. distillationThe solvent from the reaction mixture was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-2e393813214042aab9676ad8c8785296
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987444B2

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