2-Fluorophenylboronic acid → HCID 86670767, 화합물

HRID 878167노트

반응식

HRID 878167 반응식
[F:1][CH:2]([F:36])[CH2:3][N:4]([C:21]1[CH:22]=[N:23][CH:24]=[CH:25][C:26]=1[C:27]1[CH:32]=[CH:31][C:30](F)=[CH:29][C:28]=1OC)C(=O)C1C=C(C(F)(F)F)N=C(C(F)(F)F)C=1.[F:37]C1C=CC=CC=1B(O)O>CCCCCCC.CCOC(C)=O>[F:1][CH:2]([F:36])[CH2:3][NH:4][C:21]1[CH:22]=[N:23][CH:24]=[CH:25][C:26]=1[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[F:37]

참가 물질

4

반응물 2

HCID 27343542-Fluorophenylboronic acidHCID 60198028HCID 60198028, 화합물2회

생성물 1

HCID 86670767HCID 86670767, 화합물

시약·촉매·용매 1

HCID 21899848Ethylacetate heptane용매

실험 절차

The title compound was prepared in analogy to example 72, from (2,2-difluoro-ethyl)-(4-iodo-pyridin-3-yl)-amine (example 153, intermediate b) and 2-fluorophenylboronic acid (CAS RN 1193-03-9) and using a gradient of n-heptane:EtOAc (100:0 to 50:50) for the chromatographic purification. Colorless solid (87%). MS (ESI): m/z=252.1 [M+H]+.

후처리

  1. customfor the chromatographic purification

출처 및 근거

ORD 기록
ord-6c5300a2bc18480081c6d709946cfb22
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987307B2

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