2,3-Dimethoxybenzeneboronic acid → HCID 70663228, 화합물

HRID 878190

반응식

HRID 878190 반응식
F[C:2]1[C:7](F)=[CH:6][C:5]([C:9]2[CH:14]=[CH:13][N:12]=[CH:11][C:10]=2[N:15]([CH2:32]CS(C)(=O)=O)C(=O)C2C=C(C(F)(F)F)N=C(C(F)(F)F)C=2)=[C:4]([O:38][CH3:39])[CH:3]=1.[CH3:40][O:41]C1C(OC)=CC=CC=1B(O)O>CCCCCCC.CCOC(C)=O>[CH3:39][O:38][C:4]1[C:3]([O:41][CH3:40])=[CH:2][CH:7]=[CH:6][C:5]=1[C:9]1[CH:14]=[CH:13][N:12]=[CH:11][C:10]=1[NH:15][CH3:32]

참가 물질

4

반응물 2

HCID 51564912,3-Dimethoxybenzeneboronic acidHCID 86670771HCID 86670771, 화합물2회

생성물 1

HCID 70663228HCID 70663228, 화합물

시약·촉매·용매 1

HCID 21899848Ethylacetate heptane용매

실험 절차

The title compound was prepared in analogy to example 72, from (4-iodo-pyridin-3-yl)-methyl-amine (example 98, intermediate b) and 2,3-dimethoxyphenylboronic acid (CAS RN 28611-39-4) and using a gradient of n-heptane:EtOAc (100:0 to 30:70) for the chromatographic purification. Light yellow solid (79%). MS (ESI): m/z=245.128 [M+H]+.

후처리

  1. customfor the chromatographic purification

출처 및 근거

ORD 기록
ord-c369cf86c47b4affa9f9d9bf4de5ead8
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987307B2

연결된 노트

불러오는 중…