(2-Fluoro-6-methoxyphenyl)boronic acid → HCID 70663267, 화합물
반응식
F[C:2]1[C:7](F)=[CH:6][C:5]([C:9]2[CH:14]=[CH:13][N:12]=[CH:11][C:10]=2[N:15](CCS(C)(=O)=O)[C:16](=O)C2C=C(C(F)(F)F)N=C(C(F)(F)F)C=2)=[C:4]([O:38][CH3:39])[CH:3]=1.[F:40]C1C=CC=C(OC)C=1B(O)O>CCCCCCC.CCOC(C)=O>[F:40][C:6]1[CH:7]=[CH:2][CH:3]=[C:4]([O:38][CH3:39])[C:5]=1[C:9]1[CH:14]=[CH:13][N:12]=[CH:11][C:10]=1[NH:15][CH3:16]참가 물질
4
실험 절차
The title compound was prepared in analogy to Example 72, from (4-iodo-pyridin-3-yl)-methyl-amine (example 36, intermediate b) and 2-fluoro-6-methoxyphenylboronic acid (CAS RN 78495-63-3) and using a gradient of n-heptane:EtOAc (100:0 to 0:100) for the chromatographic purification. Light yellow oil (65%). MS (ESI): m/z=233.109 [M+H]+.
후처리
- customfor the chromatographic purification
출처 및 근거
- ORD 기록
- ord-da6a590c114642c5b290e42a9ae16606
- 출처 데이터셋
- uspto-grants-2015_03
- 특허 번호
- US08987307B2
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