2,6-Difluoro-3-methoxybenzeneboronic acid → [4-(2,6-Difluoro-3-methoxy-phenyl)-pyridin-3-yl]-methyl-amine

HRID 878325노트

반응식

HRID 878325 반응식
COC1N=C([C:9]2[CH:14]=[CH:13][N:12]=[CH:11][C:10]=2[N:15](C)[C:16](=O)C2C=C(C(F)(F)F)C=C(C(F)(F)F)C=2)C=CC=1.[F:33][C:34]1[C:39]([O:40][CH3:41])=[CH:38][CH:37]=[C:36]([F:42])[C:35]=1B(O)O>CCCCCC.CCOC(C)=O>[F:33][C:34]1[C:39]([O:40][CH3:41])=[CH:38][CH:37]=[C:36]([F:42])[C:35]=1[C:9]1[CH:14]=[CH:13][N:12]=[CH:11][C:10]=1[NH:15][CH3:16]

참가 물질

4

반응물 2

HCID 27831312,6-Difluoro-3-methoxybenzeneboronic acidHCID 60196806N-(6-Methoxy-[2,4']bipyridinyl-3'-yl)-N-methyl-3,5-bis-trifluoromethyl-benzamide

생성물 1

HCID 70663575[4-(2,6-Difluoro-3-methoxy-phenyl)-pyridin-3-yl]-methyl-amine

시약·촉매·용매 1

HCID 21226206Ethyl acetate hexane용매

실험 절차

The title compound was prepared in analogy to compound 284, intermediate, from (4-iodo-pyridin-3-yl)-methyl-amine (example 98, intermediate) and 2,6-difluoro-3-methoxyphenylboronic acid and using a gradient of n-hexane:EtOAc (70:30 to 60:40) for the chromatographic purification. Brown solid (75%). MS (ESI): m/z=251.2 [M+H]+.

후처리

  1. customfor the chromatographic purification

출처 및 근거

ORD 기록
ord-4f5d57f48af24ae18c882602ee18fb9d
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987307B2

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