2,4-Dichlorobenzyl alcohol → 2-[5-[(2,4-Dichlorophenyl)methoxy]pyrazol-1-yl]pyridine-4-carbonitrile

HRID 878585

반응식

HRID 878585 반응식
[OH:1][C:2]1[N:6]([C:7]2[CH:12]=[C:11]([C:13]#[N:14])[CH:10]=[CH:9][N:8]=2)[N:5]=[CH:4][CH:3]=1.[Cl:15][C:16]1[CH:21]=[C:20]([Cl:22])[CH:19]=[CH:18][C:17]=1[CH2:23]O>>[Cl:15][C:16]1[CH:21]=[C:20]([Cl:22])[CH:19]=[CH:18][C:17]=1[CH2:23][O:1][C:2]1[N:6]([C:7]2[CH:12]=[C:11]([C:13]#[N:14])[CH:10]=[CH:9][N:8]=2)[N:5]=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 156842,4-Dichlorobenzyl alcoholHCID 178510213HCID 178510213, 화합물

생성물 1

HCID 867255532-[5-[(2,4-Dichlorophenyl)methoxy]pyrazol-1-yl]pyridine-4-carbonitrile

실험 절차

The title compound was prepared from 2-(5-hydroxy-1H-pyrazol-1-yl)pyridine-4-carbonitrile and (2,4-dichlorophenyl)methanol according to the procedure for the preparation of Example 39, part C. 1H NMR (400 MHz, CDCl3): δ 5.29 (2H, s), 5.79 (1H, d, J=1.6 Hz), 7.29-7.32 (1H, m), 7.42 (1H, dd, J=1.2, 5.2 Hz), 7.45 (1H, d, J=2.4 Hz), 7.53 (1H, d, J=8.4 Hz), 7.59 (1H, d, J=1.6 Hz), 8.06 (1H, s), 8.71 (1H, d, J=4.8 Hz). [M+H] Calc'd for C16H10Cl2N4O, 345; Found, 345.

출처 및 근거

ORD 기록
ord-a697f312bfe14371a045d59fefed2393
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987461B2

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