Methyl 4-ethyl-3-nitrobenzoate → 3-AMino-4-ethyl-benzoic acid Methyl ester

HRID 878595

반응식

HRID 878595 반응식
[CH2:1]([C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][C:4]=1[N+:13]([O-])=O)[CH3:2]>[Pd].CO>[NH2:13][C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][C:3]=1[CH2:1][CH3:2])[C:7]([O:9][CH3:10])=[O:8]

참가 물질

4

반응물 1

HCID 21938352Methyl 4-ethyl-3-nitrobenzoate

생성물 1

HCID 133999993-AMino-4-ethyl-benzoic acid Methyl ester수율 94%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

Charged methyl 4-ethyl-3-nitrobenzoate (5.0 g, 23.92 mmol), Pd/C (500 mg) and methanol (50 mL) to a flask, purged with hydrogen and stirred at r.t. overnight. It was then filtered and concentrated to give 4.0 g of the title compound (94%). 1H NMR (400 MHz, CDCl3): δ 1.26 (3H, t, J=7.6 Hz), 2.54 (2H, q, J=7.6 Hz), 3.73 (2H, s), 3.87 (3H, s), 7.12 (1H, d, J=8.0 Hz), 7.35 (1H, s), 7.41 (1H, d, J=7.6 Hz). [M+H] Calc'd for C10H13NO2, 180; Found, 180.

후처리

  1. custompurged with hydrogen
  2. filtrationIt was then filtered
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-c7b108cb7f174fa7afa8e7d3f0c0f03a
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987461B2

연결된 노트

불러오는 중…