Potassium Carbonate → 2-[4-[2-[(4-Fluorophenyl)methyl-methylamino]ethyl]pyrazol-1-yl]pyridine-4-carbonitrile

참여 물질

역할	이름	HCID	투입량
반응물	Potassium Carbonate	HCID 11430	—
반응물	1-(4-fluorophenyl)-N-methylmethanamine	HCID 736860	—
반응물	2-[1-(4-Cyanopyridin-2-yl)pyrazol-4-yl]ethyl methanesulfonate	HCID 86725665	—
용매	Acetonitrile	HCID 6342	—
생성물	2-[4-[2-[(4-Fluorophenyl)methyl-methylamino]ethyl]pyrazol-1-yl]pyridine-4-carbonitrile	HCID 86725664	50.3%

반응 조건

온도	80 °C

반응 단계

To a mixture of 2-[1-(4-cyanopyridin-2-yl)pyrazol-4-yl]ethyl methanesulfonate (476 mg, 1.6 mmol) and (4-fluoro-benzyl)-methyl-amine (444 mg, 3.2 mmol) in ACN (30 mL) at rt was added K2CO3 (4.5 g, 32 mmol) and KI (1.0 g, 6.2 mmol. The reaction mixture was heated to 80° C. and stirred overnight. Filtered, solvent removed and purified by prep-HPLC to give the title compound (270 mg, 50%). [M+H] Calc'd for C19H18FN5, 336; Found, 336.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08987461B2
출처 데이터셋	uspto-grants-2015_03
ORD ID	ord-89e19dcb208b474e9683f7b400a39001
출처 메모	uspto-grants-2015_03