Potassium methyl malonate → Methyl 4-(3,5-dichlorophenyl)-3-oxobutanoate

반응식

[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=O)[CH:5]=[C:6]([Cl:8])[CH:7]=1.[K+].[CH3:14][O:15][C:16](=[O:21])[CH2:17]C([O-])=O>>[Cl:8][C:6]1[CH:5]=[C:4]([CH2:9][C:10](=[O:12])[CH2:17][C:16]([O:15][CH3:14])=[O:21])[CH:3]=[C:2]([Cl:1])[CH:7]=1

참가 물질

반응물 2

HCID 2724687Potassium methyl malonate

HCID 64524872-(3,5-Dichlorophenyl)acetic acid

생성물 1

HCID 86725683Methyl 4-(3,5-dichlorophenyl)-3-oxobutanoate수율 78%

실험 절차

The title compound was prepared in 78% yield from 2-(3,5-dichlorophenyl)acetic acid and 3-methoxy-3-oxopropanoic acid potassium salt according to the procedure for the preparation of Example 170, part A.

출처 및 근거

ORD 기록: ord-e436b245bcf84ee496559c1e59ada50d
출처 데이터셋: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08987461B2

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