참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | (2-Nitrophenyl)hydrazine | HCID 3314739 | — |
| 반응물 | 2,3-Dioxo-2,3-dihydro-1H-indole-5-sulfonic acid (furan-2-ylmethyl)amide | HCID 59763031 | — |
| 촉매 | Hydrochloric Acid | HCID 313 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | HCID 178517309 | HCID 178517309 | — |
반응 단계
A mixture of rpm161 (0.040 g, 0.114 mmol) 2-nitrophenylhydrazine (0.021 g, 0.126 mmol, 1.1 eq) and HCl (aq 4 M, 2 drops) in ethanol (3 mL) was heated in the CEM microwave at 120° C. for 15 min. After cooling to room temperature, pure product rpm168 was collected as an orange precipitate by filtration and dried in vacuo. The pure compound rpm168 was obtained without further purification (0.048 g, 0.099 mmol, 86%). MS (API-ES): m/z 459 (M+NH4)+; HRMS (API-ES) m/z Found: 459.1082 (M+NH4)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08987474B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_03 |
|---|
| ORD ID | ord-3013d6af1a784f6da467cae0cdc17c3c |
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| 출처 메모 | uspto-grants-2015_03 |
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