Potassium Hydroxide → potassium 2-[1-(2,6-dichlorobenzyl)-3-methyl-1H-indazole-6-yl]acetate

HRID 878996노트

반응식

HRID 878996 반응식
[Cl:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([Cl:23])[C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([CH2:14][C:15]([OH:17])=[O:16])[CH:12]=2)[C:7]([CH3:18])=[N:6]1.[OH-].[K+:25]>C(O)C>[Cl:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([Cl:23])[C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([CH2:14][C:15]([O-:17])=[O:16])[CH:12]=2)[C:7]([CH3:18])=[N:6]1.[K+:25]

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 60152151HCID 60152151, 화합물

생성물 1

HCID 131732622potassium 2-[1-(2,6-dichlorobenzyl)-3-methyl-1H-indazole-6-yl]acetate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of the compound [97](118 mg) in ethanol (5 mL) was added an aqueous solution of 1N-potassium hydroxide (0.34 mL) at room temperature, and then the reaction mixture was stirred at room temperature for 10 minutes. The reaction mixture was concentrated under reduced pressure to give the titled compound (128 mg) as a white solid.

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-3b0f27bfeff34be3a00018d1257bb4fd
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987473B2

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