5-Bromo-3-fluoropyridine-2-carbonitrile → HCID 178437984, 화합물

HRID 879011노트

반응식

HRID 879011 반응식
[Br:1][C:2]1[CH:3]=[C:4](F)[C:5]([C:8]#[N:9])=[N:6][CH:7]=1.[CH2:11]([Mg]Cl)[CH3:12].ClC1C=CC=C(Cl)C=1C[N:19]1C2C(=NC=C(C(O)=O)C=2)C(C)=N1>>[Br:1][C:2]1[CH:3]=[C:4]2[NH:19][N:9]=[C:8]([CH2:11][CH3:12])[C:5]2=[N:6][CH:7]=1

참가 물질

4

반응물 3

HCID 441966805-Bromo-3-fluoropyridine-2-carbonitrileHCID 681838111-(2,6-dichlorobenzyl)-3-methyl-1H-pyrazolo[4,3-b]pyridine-6-carboxylic acidHCID 178461633HCID 178461633, 화합물

생성물 1

HCID 178437984HCID 178437984, 화합물

실험 절차

The titled compound (225 mg) as a white solid was prepared from 5-bromo-3-fluoropyridin-2-carbonitrile (201 mg) obtained by the method described in the document (Journal of Organic Chemistry, 2009, Vol. 74, p. 4547) and ethylmagnesium chloride according to the methods of the processes (1) and (2) of Example 153.

후처리

  1. customobtained by the method

출처 및 근거

ORD 기록
ord-a90160fa915f486fa7ce01beb295c1c4
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987473B2

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