Trimethylsilyldiazomethane → HCID 75445982, 화합물

HRID 879704노트

반응식

HRID 879704 반응식
[C:1]([O:5][C:6]([NH:8][C:9]1[S:10][C:11]([C:15]([OH:17])=[O:16])=[C:12]([CH3:14])[N:13]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Si](C=[N+]=[N-])(C)(C)[CH3:19]>C1COCC1.CO>[CH3:19][O:16][C:15]([C:11]1[S:10][C:9]([NH:8][C:6]([O:5][C:1]([CH3:4])([CH3:2])[CH3:3])=[O:7])=[N:13][C:12]=1[CH3:14])=[O:17]

참가 물질

4

반응물 2

HCID 167693TrimethylsilyldiazomethaneHCID 2756770N-Boc-amino-4-methylthiazole-5-carboxylic acid

생성물 1

HCID 75445982HCID 75445982, 화합물

시약·촉매·용매 1

HCID 21899815MeOH tetrahydrofuran용매

실험 절차

2-tert-Butoxycarbonylamino-4-methyl-thiazole-5-carboxylic acid (0.52 g) was dissolved in THF: MeOH (2:1, 10 mL) and 2 eq of TMSCHN2 (2M sln in hex) was added at RT and stirred for 6 h. All volatiles were removed in vacuum by rotavap and the residue was dried in vacuum to give 2-tert-Butoxycarbonylamino-4-methyl-thiazole-5-carboxylic acid methyl ester (0.52 g). This was used in the next reaction without further purification. 1H NMR (400 MHz, CDCl3) 3.83 (s, 3H), 2.65 (s, 3H), 1.54 (s, 9H).

후처리

  1. customAll volatiles were removed in vacuum by rotavap
  2. customthe residue was dried in vacuum

출처 및 근거

ORD 기록
ord-5a5b606ced7b425ea07c158f5cec6b64
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987295B2

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