Triethylamine → HCID 178523576, 화합물

HRID 880034

반응식

HRID 880034 반응식
[OH:1][C:2]1[C:3](=[O:11])[NH:4][CH:5]=[CH:6][C:7]=1[C:8](Cl)=[O:9].[C:12]1([C@@H:18]2[CH2:23][CH2:22][C@H:21]([NH2:24])[CH2:20][CH2:19]2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.CCN(CC)CC>C(Cl)Cl>[OH:1][C:2]1[C:3](=[O:11])[NH:4][CH:5]=[CH:6][C:7]=1[C:8]([NH:24][C@H:21]1[CH2:20][CH2:19][C@@H:18]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:23][CH2:22]1)=[O:9]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 867300873-Hydroxy-2-oxo-1,2-dihydropyridine-4-carbonyl chloride2회HCID 178418405HCID 178418405, 화합물2회

생성물 1

HCID 178523576HCID 178523576, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 3-hydroxy-2-oxo-1,2-dihydropyridine-4-carbonyl chloride (Intermediate 17) (38.1 mg, 0.219 mmol) and cis-4-phenylcyclohexanamine (Intermediate 14) (50 mg, 0.29 mmol) in DCM (1 mL) was added Et3N (0.061 mL, 0.44 mmol). The reaction mixture was stirred at rt for 1 h. The reaction mixture was partitioned between H2O and DCM. The DCM layer was dried over Na2SO4 and filtered through a silica gel plug. The solvent was removed under reduced pressure to give Example 36A which was used without further purification.

후처리

  1. customThe reaction mixture was partitioned between H2O and DCM
  2. dry with materialThe DCM layer was dried over Na2SO4
  3. filtrationfiltered through a silica gel plug
  4. customThe solvent was removed under reduced pressure
  5. customto give Example 36A which
  6. customwas used without further purification

출처 및 근거

ORD 기록
ord-44906a32281c4353b07466489919940a
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08993557B2

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