3-(Cyclopentyloxy)aniline → HCID 136352196, 화합물

HRID 880104노트

반응식

HRID 880104 반응식
[N:1]1([C:7]2[N:8]=[C:9]([CH2:14][C:15]([O-:17])=O)[NH:10][C:11](=[O:13])[CH:12]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Na+].[CH:19]1([O:24][C:25]2[CH:26]=[C:27]([CH:29]=[CH:30][CH:31]=2)[NH2:28])[CH2:23][CH2:22][CH2:21][CH2:20]1>>[CH:19]1([O:24][C:25]2[CH:26]=[C:27]([NH:28][C:15](=[O:17])[CH2:14][C:9]3[NH:10][C:11](=[O:13])[CH:12]=[C:7]([N:1]4[CH2:2][CH2:3][O:4][CH2:5][CH2:6]4)[N:8]=3)[CH:29]=[CH:30][CH:31]=2)[CH2:23][CH2:22][CH2:21][CH2:20]1

참가 물질

3

반응물 2

HCID 167830523-(Cyclopentyloxy)anilineHCID 136041844Sodium (4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetate

생성물 1

HCID 136352196HCID 136352196, 화합물수율 67.8%

실험 절차

The product is prepared according to the procedure described in Example 5, using 260 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 354 mg of 3-(cyclopentyloxy)aniline in place of the 2,4-difluoroaniline. 269 mg of N-[3-(cyclopentyloxy)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following:

후처리

  1. customThe product is prepared

출처 및 근거

ORD 기록
ord-ec857d41e8d547fdac594fa685b96835
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08993565B2

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