Ammonium Hydroxide → (S)-1-Amino-3-(3,4-dihydroisoquinolin-2(1H)-yl)propan-2-ol

HRID 880251노트

반응식

HRID 880251 반응식
[O:1]1[CH2:3][C@H:2]1[CH2:4][N:5]1[CH2:14][CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6]1.[NH4+:15].[OH-]>CCO>[NH2:15][CH2:3][C@H:2]([OH:1])[CH2:4][N:5]1[CH2:14][CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6]1

참가 물질

4

반응물 2

HCID 14923Ammonium HydroxideHCID 30076569(R)-2-(oxiran-2-ylmethyl)-1,2,3,4-tetrahydroisoquinoline

생성물 1

HCID 25312355(S)-1-Amino-3-(3,4-dihydroisoquinolin-2(1H)-yl)propan-2-ol

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
100 °C

실험 절차

To a solution of (R)-2-(oxiran-2-ylmethyl)-1,2,3,4-tetrahydroisoquinoline (200 mg, 5.2 mmol) in EtOH (20 mL) was added NH4OH (600 mg, 35.2 mmol) at −78° C. The reaction mixture was then warmed and heated at 100° C. for 3 h in a seal tube. The reaction mixture was concentrated and the crude product was used in next step without further purification. LCMS (m/z): 207.1 (M+1).

후처리

  1. temperatureThe reaction mixture was then warmed
  2. concentrationThe reaction mixture was concentrated
  3. customthe crude product was used in next step without further purification

출처 및 근거

ORD 기록
ord-da741157519d4e53878e3a1bcd2eb1ee
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08993555B2

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