Potassium Cyanide → 2-(Propan-2-yl)butanedinitrile

HRID 880421노트

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HRID 880421 반응식
[C-:1]#[N:2].[K+].[C:4]([C:6](=[CH:12][CH:13]([CH3:15])[CH3:14])C(OCC)=O)#[N:5]>O.C(O)C>[CH:13]([CH:12]([CH2:6][C:4]#[N:5])[C:1]#[N:2])([CH3:14])[CH3:15]

참가 물질

5

반응물 2

HCID 9032Potassium CyanideHCID 54168338HCID 54168338, 화합물

생성물 1

HCID 1368682-(Propan-2-yl)butanedinitrile수율 74%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

A solution of potassium cyanide (5.81 g, 89.52 mmol) in water (12 mL) was added to a solution of ethyl 2-cyano-4-methyl-pent-2-enoate (6.5 g, 38.92 mmol) in ethanol (20 mL) at room temperature and the reaction mixture was stirred overnight. The resulting mixture was refluxed for 2 h and then cooled to room temperature. The ethanol was evaporated and the residue dissolved in dichloromethane. The dichloromethane layer was washed with water and brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 2-isopropylbutanedinitrile (3.5 g, 74%) as a liquid.

후처리

  1. temperatureThe resulting mixture was refluxed for 2 h
  2. customThe ethanol was evaporated
  3. dissolutionthe residue dissolved in dichloromethane
  4. washThe dichloromethane layer was washed with water and brine
  5. dry with materialdried over anhydrous sodium sulfate
  6. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-b613ab7d7e274f93bf3ca0d5c5e81b17
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08993574B2

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