Triethylamine → Methyl 2-methyl-4,5-dihydro-1,3-oxazole-4-carboxylate
반응식
[CH2:1](N(CC)CC)[CH3:2].CCl.[NH2:10][C@H:11]([C:14]([OH:16])=[O:15])[CH2:12][OH:13].Cl.[CH2:18](OC(=N)C)C>ClCCl>[CH3:1][C:2]1[O:13][CH2:12][CH:11]([C:14]([O:16][CH3:18])=[O:15])[N:10]=1참가 물질
5
실험 절차
Triethylamine (5.86 g, 58.01 mmol) was added to a suspension of L-serine methyl hydrochloride (4.5 g, 29.03 mmol) and ethylacetimidate hydrochloride (4.3 g, 34.95 mmol) in dichloromethane (40 mL) at 0° C. over a period of 20 min. The mixture was then stirred at ambient temperature for 18 h. The suspension was filtered and washed with diethyl ether. The solid which precipitated from the filtrate was again filtered and washed with diethyl ether. The resulting filtrate was dried over anhydrous sodium sulfate and concentrated in vacuo to afford methyl 2-methyl-4,5-dihydrooxazole-4-carboxylate (3 g, 72%) as a liquid.
후처리
- filtrationThe suspension was filtered
- washwashed with diethyl ether
- customThe solid which precipitated from the filtrate
- filtrationwas again filtered
- washwashed with diethyl ether
- dry with materialThe resulting filtrate was dried over anhydrous sodium sulfate
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-5ba83008ff2e46b78f47f806272b42eb
- 출처 데이터셋
- uspto-grants-2015_03
- 특허 번호
- US08993574B2
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