Potassium tert-butoxide → HCID 24937079, 화합물

HRID 880669

반응식

HRID 880669 반응식
[CH3:1][C:2]([CH3:5])([O-])[CH3:3].[K+].Br[C:8]1[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[C:11]([NH:18][C:19](=[O:25])[CH2:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[C:10]([Cl:26])[CH:9]=1>C1(C)C=CC=CC=1>[Cl:26][C:10]1[CH:9]=[C:8]([N:18]2[CH2:19][CH2:20][C:5]3[C:2](=[CH:3][CH:11]=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:13]=3)[CH2:1]2)[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[C:11]=1[NH:18][C:19](=[O:25])[CH2:20][C:21]([CH3:24])([CH3:23])[CH3:22]

참가 물질

4

반응물 2

HCID 23665647Potassium tert-butoxideHCID 58097337N-(4-bromo-2-chloro-6-(trifluoromethyl)phenyl)-3,3-dimethylbutanamide

생성물 1

HCID 24937079HCID 24937079, 화합물

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

Bis(dibenzylidineacetone)palladium (2 mg, 0.0035 mmol) and (2′-dicyclohexyl phosphanyl-biphenyl-2-yl)-dimethylamine (3.3 mg, 0.0084 mmol) were added to dry toluene (10 mL purged with argon) and stirred for 15 minutes under argon. Potassium tert-butoxide (197 mg, 1.75 mmol), 6-trifluoro-1,2,3,4-tetrahydroisoquinoline (154 mg, 0.65 mmol) and N-(4-bromo-2-chloro-6-(trifluoromethyl)phenyl)-3,3-dimethylbutanamide (200 mg, 0.54 mmol) were then added, and the reaction mixture was stirred at 90° C. overnight. The reaction mixture was then cooled to room temperature, concentrated, and purified by thin layer chromatography (dichloromethane:methanol 5%) to afford the title compound as a solid

후처리

  1. stirringthe reaction mixture was stirred at 90° C. overnight
  2. concentrationconcentrated
  3. custompurified by thin layer chromatography (dichloromethane:methanol 5%)

출처 및 근거

ORD 기록
ord-4b13d69a0560437696f78999794fd418
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08993593B2

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