Water → N-(4-Bromo-2,6-dimethyl-phenyl)-3,3-dimethyl-butanamide

HRID 880673

반응식

HRID 880673 반응식
[CH3:1][C:2]([CH3:8])([CH3:7])[CH2:3][C:4](Cl)=[O:5].C(N(CC)CC)C.[Br:16][C:17]1[CH:22]=[C:21]([CH3:23])[C:20]([NH2:24])=[C:19]([CH3:25])[CH:18]=1.O>C(#N)C>[Br:16][C:17]1[CH:22]=[C:21]([CH3:23])[C:20]([NH:24][C:4](=[O:5])[CH2:3][C:2]([CH3:8])([CH3:7])[CH3:1])=[C:19]([CH3:25])[CH:18]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 8471TriethylamineHCID 815143,3-Dimethylbutanoyl chlorideHCID 905494-Bromo-2,6-xylidine

생성물 1

HCID 59741059N-(4-Bromo-2,6-dimethyl-phenyl)-3,3-dimethyl-butanamide수율 100.1%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

3,3-Dimethylbutanoyl chloride (3.37 g, 3.5 mL, 25 mmol) and triethylamine (2.53 g, 3.5 mL, 25 mmol) were added to a solution of 4-bromo-2,6-dimethyl phenylamine (5.0 g, 25 mmol) in acetonitrile (30 mL). The reaction mixture was stirred at room temperature for 4 hours. Water was added to the mixture and the precipitate formed collected to give the title compound as a powder (7.46 g, 100% yield).

후처리

  1. customthe precipitate formed
  2. customcollected

출처 및 근거

ORD 기록
ord-3752720813b14977b97d99b747cf7405
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08993593B2

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