7-bromo-N-methylisoquinolin-3-amine → 3-(Methylamino)isoquinoline-7-carboxylic acid
반응식
FC(F)(F)[C:3]1[CH:4]=[C:5]([C:12]([OH:14])=[O:13])[CH:6]=[C:7]2[C:11]=1N[N:9]=[CH:8]2.BrC1C=C2C([CH:22]=[C:23](NC)[N:24]=[CH:25]2)=CC=1>>[CH3:25][NH:24][C:23]1[N:9]=[CH:8][C:7]2[C:11]([CH:22]=1)=[CH:3][CH:4]=[C:5]([C:12]([OH:14])=[O:13])[CH:6]=2참가 물질
3
실험 절차
The title compound was prepared by a method analogous to that described in Steps 3-4 of Intermediate 21, using 7-bromo-N-methylisoquinolin-3-amine. +ESI (M+H) 203.1; 1H NMR (400 MHz, CD3OD, δ): 8.87 (s, 1H), 8.51 (s, 1H), 7.98 (dd, J=8.88, 1.66 Hz, 1H), 7.58 (d, J=8.78 Hz, 1H), 6.60 (s, 1H), 2.93 (s, 3H).
출처 및 근거
- ORD 기록
- ord-170a7dd6410141b1869059b29deb34f0
- 출처 데이터셋
- uspto-grants-2015_03
- 특허 번호
- US08993586B2
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