N,N-dimethyl-2-(piperazin-1-yl)acetamide → 2-[4-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperazin-1-yl]-N,N-dimethyl-acetamide

HRID 881296

반응식

HRID 881296 반응식
[Cl:1][C:2]1[N:3]=[C:4]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:5]2[S:10][C:9]([CH:11]=O)=[CH:8][C:6]=2[N:7]=1.[CH3:19][N:20]([CH3:30])[C:21](=[O:29])[CH2:22][N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>>[Cl:1][C:2]1[N:3]=[C:4]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:5]2[S:10][C:9]([CH2:11][N:26]3[CH2:25][CH2:24][N:23]([CH2:22][C:21]([N:20]([CH3:30])[CH3:19])=[O:29])[CH2:28][CH2:27]3)=[CH:8][C:6]=2[N:7]=1

참가 물질

3

반응물 2

HCID 2758642N,N-dimethyl-2-(piperazin-1-yl)acetamideHCID 457899852-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde

생성물 1

HCID 574939702-[4-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperazin-1-yl]-N,N-dimethyl-acetamide

실험 절차

Reaction between 2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidine-6-carbaldehyde 10 (Example 3) and N,N-dimethyl-2-piperazin-1-yl-acetamide using General Procedure B-3 yielded 2-[4-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperazin-1-yl]-N,N-dimethyl-acetamide.

출처 및 근거

ORD 기록
ord-71e17f0ade914eedb2f927607307d8cf
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08993563B2

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