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Water → Methyl 2-(4-(4'-(2-ethyl-4-methyloxazole-5-carboxamido)-[1,1'-biphenyl]-4-yl)-2-oxabicyclo[2.2.2]octan-1-yl)acetate

HRID 881735
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HRID 881735 반응식
[CH2:1]([C:3]1[O:4][C:5]([C:9]([NH:11][C:12]2[CH:17]=[CH:16][C:15](B3OC(C)(C)C(C)(C)O3)=[CH:14][CH:13]=2)=[O:10])=[C:6]([CH3:8])[N:7]=1)[CH3:2].Br[C:28]1[CH:33]=[CH:32][C:31]([C:34]23[CH2:41][CH2:40][C:37]([CH2:42][C:43]([O:45][CH3:46])=[O:44])([CH2:38][CH2:39]2)[O:36][CH2:35]3)=[CH:30][CH:29]=1.O.[F-].[Cs+]>O1CCOCC1.CC(P(C(C)(C)C)C1C=CC(N(C)C)=CC=1)(C)C.CC(P(C(C)(C)C)C1C=CC(N(C)C)=CC=1)(C)C.Cl[Pd]Cl>[CH2:1]([C:3]1[O:4][C:5]([C:9]([NH:11][C:12]2[CH:13]=[CH:14][C:15]([C:28]3[CH:29]=[CH:30][C:31]([C:34]45[CH2:39][CH2:38][C:37]([CH2:42][C:43]([O:45][CH3:46])=[O:44])([CH2:40][CH2:41]4)[O:36][CH2:35]5)=[CH:32][CH:33]=3)=[CH:16][CH:17]=2)=[O:10])=[C:6]([CH3:8])[N:7]=1)[CH3:2]
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참가 물질

7

반응물 4

HCID 962WaterHCID 25953Cesium fluorideHCID 86700823Methyl 2-(4-(4-bromophenyl)-2-oxabicyclo[2.2.2]octan-1-yl)acetateHCID 867008392-ethyl-4-methyl-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)oxazole-5-carboxamide

생성물 1

HCID 86700840Methyl 2-(4-(4'-(2-ethyl-4-methyloxazole-5-carboxamido)-[1,1'-biphenyl]-4-yl)-2-oxabicyclo[2.2.2]octan-1-yl)acetate
수율 58%

시약·촉매·용매 2

HCID 11714597Bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II)촉매HCID 312751,4-Dioxane용매

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온도
90 °C

실험 절차

To a solution of 2-ethyl-4-methyl-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)oxazole-5-carboxamide (200 mg, 0.561 mmol) and methyl 2-(4-(4-bromophenyl)-2-oxabicyclo[2.2.2]octan-1-yl)acetate (190 mg, 0.561 mmol) in dioxane (3 ml) was added H2O (0.33 ml). CsF (256 mg, 1.684 mmol) and Pd(amphos)Cl2 (39.8 mg, 0.056 mmol) were then added and the mixture was degassed before being heated at 90° C. for overnight. The reaction mixture was then cooled to room temperature and directly purified by column chromatography to afford the title compound as white solid after drying (159 mg, 58% yield). LC/MS, ESI-MS(+): 489.0, RT: 1.40 (Condition E).

후처리

  1. customthe mixture was degassed
  2. temperatureThe reaction mixture was then cooled to room temperature
  3. customdirectly purified by column chromatography

출처 및 근거

ORD 기록
ord-70f9ecb5f4e2449cb0ad6a3cb5142a91
출처 데이터셋
uspto-grants-2015_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08993619B2

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