참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Methyl 3-butenoate | HCID 77314 | — |
| 반응물 | 6-Iodo-2-methyl-1,3-benzothiazole | HCID 807592 | — |
| 촉매 | palladium(II) acetate | HCID 167845 | — |
| 생성물 | (E)-4-(2-methyl-benzothiazol-6-yl)-but-3-enoic acid methyl ester | HCID 67505910 | — |
반응 단계
A mixture of 6-iodo-2-methylbenzo[d]thiazole (275 mg, 1 mmol), but-3-enoic acid methyl ester (100 mg, 1.2 mmol), diacetoxypalladium (22 mg, 0.1 mmol) and triethylamine (304 mg, 3 mmol) MeCN (8 mL) is heated in a microwave apparatus at 130° C. for 30 minutes. The solvent is removed under reduce pressure and the residue is purified by flash chromatography (heptane:EtOAc, 2:1) to give (E)-4-(2-methyl-benzothiazol-6-yl)-but-3-enoic acid methyl ester. MS 248.3 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08993631B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_03 |
|---|
| ORD ID | ord-2a3f1c955a9747068aef64fbe92f7eb1 |
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| 출처 메모 | uspto-grants-2015_03 |
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