2-fluoro-3-methoxy-N-methyl-6-nitroaniline → 3-fluoro-4-methoxy-N2-methylbenzene-1,2-diamine

HRID 882204노트

반응식

HRID 882204 반응식
[F:1][C:2]1[C:9]([O:10][CH3:11])=[CH:8][CH:7]=[C:6]([N+:12]([O-])=O)[C:3]=1[NH:4][CH3:5]>C(O)(=O)C.[Fe]>[F:1][C:2]1[C:9]([O:10][CH3:11])=[CH:8][CH:7]=[C:6]([NH2:12])[C:3]=1[NH:4][CH3:5]

참가 물질

4

반응물 1

HCID 667492842-fluoro-3-methoxy-N-methyl-6-nitroaniline

생성물 1

HCID 667491243-fluoro-4-methoxy-N2-methylbenzene-1,2-diamine

시약·촉매·용매 2

HCID 23925Iron촉매HCID 176Acetic Acid용매

실험 절차

A solution of 2-fluoro-3-methoxy-N-methyl-6-nitroaniline (7-2, 1.04 g, 5.20 mmol) in Acetic acid (25 ml) was charged with Iron (powder). The resulting mixture was stirred at 23 deg C. for 22 h. The reduced material concentrated in vacuo, and the residual oil was taken up in Methylene Chloride and filtered through Celite. The filtrate was again concentrated in vacuo, leaving the title compound, 3-fluoro-4-methoxy-N2-methylbenzene-1,2-diamine (7-3), as a maroon oil with >80% purity. LRMS m/z: Calc'd for C8H11FN2O (M+H) 171.2, found 170.9.

후처리

  1. concentrationThe reduced material concentrated in vacuo
  2. filtrationfiltered through Celite
  3. concentrationThe filtrate was again concentrated in vacuo

출처 및 근거

ORD 기록
ord-50dac30034da4218bb8e8deced8d019b
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08993779B2

반응 노트

불러오는 중…