Cesium carbonate → 4-{[(2R,3S,4R,5S)-4-(4-chloro-2-fluoro-phenyl)-3-(3-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino}-3-methoxy-benzoic acid acetoxymethyl ester

반응식

[C:1]([O:4][CH2:5]I)(=[O:3])[CH3:2].[Cl:7][C:8]1[C:9]([F:48])=[C:10]([C@@H:14]2[C@:18]([C:21]3[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:22]=3[F:28])([C:19]#[N:20])[C@H:17]([CH2:29][C:30]([CH3:33])([CH3:32])[CH3:31])[NH:16][C@H:15]2[C:34]([NH:36][C:37]2[CH:45]=[CH:44][C:40]([C:41]([OH:43])=[O:42])=[CH:39][C:38]=2[O:46][CH3:47])=[O:35])[CH:11]=[CH:12][CH:13]=1.C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C)C=O.C(OCC)(=O)C>[C:1]([O:4][CH2:5][O:43][C:41](=[O:42])[C:40]1[CH:44]=[CH:45][C:37]([NH:36][C:34]([C@H:15]2[C@H:14]([C:10]3[CH:11]=[CH:12][CH:13]=[C:8]([Cl:7])[C:9]=3[F:48])[C@:18]([C:21]3[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:22]=3[F:28])([C:19]#[N:20])[C@H:17]([CH2:29][C:30]([CH3:32])([CH3:33])[CH3:31])[NH:16]2)=[O:35])=[C:38]([O:46][CH3:47])[CH:39]=1)(=[O:3])[CH3:2]