Cesium carbonate → 1-(4-((2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxamido)-3-methoxybenzoyloxy)ethyl morpholine-4-carboxylate

반응식

[N:1]1([C:7]([O:9][CH:10](Cl)[CH3:11])=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Cl:13][C:14]1[C:15]([F:54])=[C:16]([C@@H:20]2[C@:24]([C:27]3[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][C:28]=3[F:34])([C:25]#[N:26])[C@H:23]([CH2:35][C:36]([CH3:39])([CH3:38])[CH3:37])[NH:22][C@H:21]2[C:40]([NH:42][C:43]2[CH:51]=[CH:50][C:46]([C:47]([OH:49])=[O:48])=[CH:45][C:44]=2[O:52][CH3:53])=[O:41])[CH:17]=[CH:18][CH:19]=1.C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C)C=O>[N:1]1([C:7]([O:9][CH:10]([O:49][C:47](=[O:48])[C:46]2[CH:50]=[CH:51][C:43]([NH:42][C:40]([C@H:21]3[C@H:20]([C:16]4[CH:17]=[CH:18][CH:19]=[C:14]([Cl:13])[C:15]=4[F:54])[C@:24]([C:27]4[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][C:28]=4[F:34])([C:25]#[N:26])[C@H:23]([CH2:35][C:36]([CH3:38])([CH3:39])[CH3:37])[NH:22]3)=[O:41])=[C:44]([O:52][CH3:53])[CH:45]=2)[CH3:11])=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1