Acetonitrile → 3-Hydroxy-3-(3-pentyloxyphenyl)propionitrile

반응식

[CH2:1]([O:6][C:7]1[CH:8]=[C:9]([CH:12]=[CH:13][CH:14]=1)[CH:10]=[O:11])[CH2:2][CH2:3][CH2:4][CH3:5].[C:15](#[N:17])[CH3:16]>>[OH:11][CH:10]([C:9]1[CH:12]=[CH:13][CH:14]=[C:7]([O:6][CH2:1][CH2:2][CH2:3][CH2:4][CH3:5])[CH:8]=1)[CH2:16][C:15]#[N:17]

참가 물질

반응물 2

HCID 6342Acetonitrile

HCID 27603123-(Pentyloxy)benzaldehyde

생성물 1

HCID 673170353-Hydroxy-3-(3-pentyloxyphenyl)propionitrile

실험 절차

Addition of acetonitrile to 3-pentyloxybenzaldehyde gave 3-hydroxy-3-(3-pentyloxyphenyl)propionitrile as a yellow oil. Yield (1.11 g, 67%): 1H NMR (400 MHz, CDCl3) δ 7.30 (d, J=7.6 Hz, 1H), 6.92-6.98 (m, 2H), 6.87 (d, J=7.6 Hz, 1H), 5.02 (m, 1H), 3.98 (t, J=6.4 Hz, 2H), 2.76 (d, J=6.0 Hz, 2H), 1.75-1.83 (m, 2H), 1.32-1.49 (m, 4H), 0.92 (t, J=6.8 Hz, 3H).

출처 및 근거

ORD 기록: ord-7245f13578c84eafb95083e4a4469e4a
출처 데이터셋: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08993807B2

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