Cyclohexane, (bromomethyl)- → Ethyl 3-bromo-5-(cyclohexylmethoxy)benzoate

HRID 882496노트

반응식

HRID 882496 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:10]=[C:11]([OH:13])[CH:12]=1)[C:5]([O:7][CH2:8][CH3:9])=[O:6].Br[CH2:15][CH:16]1[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>>[Br:1][C:2]1[CH:3]=[C:4]([CH:10]=[C:11]([O:13][CH2:15][CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)[CH:12]=1)[C:5]([O:7][CH2:8][CH3:9])=[O:6]

참가 물질

3

반응물 2

HCID 137636Cyclohexane, (bromomethyl)-HCID 11708561Ethyl 3-bromo-5-hydroxybenzoate

생성물 1

HCID 67317627Ethyl 3-bromo-5-(cyclohexylmethoxy)benzoate

실험 절차

Alkylation of ethyl 3-bromo-5-hydroxybenzoate using (bromomethyl)cyclohexane gave ethyl 3-bromo-5-(cyclohexylmethoxy)benzoate. Yield (1.36 g, 100%): 1H NMR (400 MHz, CDCl3) δ 7.72 (t, J=1.6 Hz, 1H), 7.46 (dd, J=2.4, 1.2 Hz, 1H), 7.20 (dd, J=2.4, 1.6 Hz, 1H), 4.35 (q, J=7.2 Hz, 2H), 3.76 (d, J=6.4 Hz, 2H), 1.67-1.88 (m, 6H), 1.38 (t, J=7.2 Hz, 3H), 1.16-1.32 (m, 3H), 1.01-1.11 (m, 2H).

출처 및 근거

ORD 기록
ord-b9ad8ac2479a429fa4e94b9e7f808822
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08993807B2

반응 노트

불러오는 중…