Potassium Carbonate → HCID 69456408, 화합물

HRID 882880

반응식

HRID 882880 반응식
[SH:1][C:2]1[N:10]([CH2:11][CH:12]=[C:13]([CH3:15])[CH3:14])[C:9]2[C:8](=[O:16])[N:7]([CH2:17][C:18](=[O:25])[C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:6](=[O:26])[N:5]([CH3:27])[C:4]=2[N:3]=1.C(=O)([O-])[O-].[K+].[K+].[NH2:34][C:35]([CH3:43])([CH3:42])[CH2:36]OS([O-])(=O)=O>CN(C)C=O>[NH2:34][C:35]([CH3:43])([CH3:42])[CH2:36][S:1][C:2]1[N:10]([CH2:11][CH:12]=[C:13]([CH3:15])[CH3:14])[C:9]2[C:8](=[O:16])[N:7]([CH2:17][C:18](=[O:25])[C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:6](=[O:26])[N:5]([CH3:27])[C:4]=2[N:3]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 86616418HCID 86616418, 화합물HCID 178446233HCID 178446233, 화합물

생성물 1

HCID 69456408HCID 69456408, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

30 mg of 8-mercapto-3-methyl-7-(3-methylbut-2-enyl)-1-(2-oxo-2-phenyl-ethyl)-3,7-dihydropurine-2,6-dione were introduced into 2 ml of dimethyl-formamide and, after addition of 37 mg of potassium carbonate, stirred for 15 minutes. Then 13.5 mg of mono(2-amino-2-methylpropyl)sulfate were added, and the mixture was stirred at 80° C. for 29 hours. The volatile fractions were removed in vacuum at 40° C., and the residue was purified by column chromatography (silica gel, mobile phase: methylene chloride: methanol =95:5).

후처리

  1. stirringthe mixture was stirred at 80° C. for 29 hours
  2. customThe volatile fractions were removed in vacuum at 40° C.
  3. customthe residue was purified by column chromatography (silica gel, mobile phase: methylene chloride: methanol =95:5)

출처 및 근거

ORD 기록
ord-326e302d5bcb4874a7b6a8324a807aac
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08236810B2

연결된 노트

불러오는 중…