Diphenylsilane → 4-(4-Bromo-3-fluorobenzyl)morpholine

HRID 882966

반응식

HRID 882966 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=O)=[CH:4][C:3]=1[F:16].C1([SiH2]C2C=CC=CC=2)C=CC=CC=1>C1COCC1.C=O.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.[Rh]>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:10]2[CH2:11][CH2:12][O:13][CH2:14][CH2:15]2)=[CH:4][C:3]=1[F:16]

참가 물질

5

반응물 2

HCID 69888DiphenylsilaneHCID 48474115(4-Bromo-3-fluorophenyl)(morpholin-4-yl)methanone

생성물 1

HCID 534178184-(4-Bromo-3-fluorobenzyl)morpholine

시약·촉매·용매 2

HCID 53249357Carbonyltris(triphenylphosphine)rhodium(I)hydride촉매HCID 8028Tetrahydrofuran용매

실험 절차

A 250 ml flask was charged with (4-bromo-3-fluorophenyl)(morpholino)methanone (4.569 g, 15.86 mmol) and dissolved in 16 mL of THF. Diphenylsilane (6.2 ml, 33.4 mmol) was added followed by carbonyltris(triphenylphosphine)rhodium(I)hydride (100 mg, 0.109 mmol) and the reaction stirred at room temperature for 20 hours.

출처 및 근거

ORD 기록
ord-843b16ae77e44d478946b8a4599c9546
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08236799B2

연결된 노트

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