2-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride) → 1-Ethyl-4,4,6-trimethyl-7-(2-trifluoromethoxy-phenyl)-3,4-dihydro-1H-quinolin-2-one

HRID 883071

반응식

HRID 883071 반응식
Br[C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:16])([CH3:15])[CH2:7][C:8](=[O:14])[N:9]2[CH2:12][CH3:13])=[CH:4][C:3]=1[CH3:17].[F:18][C:19]([F:31])([F:30])[O:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1B(O)O>>[CH2:12]([N:9]1[C:10]2[C:5](=[CH:4][C:3]([CH3:17])=[C:2]([C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[O:20][C:19]([F:18])([F:31])[F:30])[CH:11]=2)[C:6]([CH3:16])([CH3:15])[CH2:7][C:8]1=[O:14])[CH3:13]

참가 물질

3

반응물 2

HCID 27772042-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride)HCID 219664867-Bromo-1-ethyl-4,4,6-trimethyl-3,4-dihydro-1H-quinolin-2-one

생성물 1

HCID 686663931-Ethyl-4,4,6-trimethyl-7-(2-trifluoromethoxy-phenyl)-3,4-dihydro-1H-quinolin-2-one

실험 절차

Compound 9A was prepared from Compound 1A using the procedure described in Example 1B, except using 2-trifluoromethoxy benzene boronic acid as the starting material. MS (electrospray): mass calculated for C21H22F3NO2 377.16; m/z found m/z found, 378.2 [M+H]+.

출처 및 근거

ORD 기록
ord-d90a840a2dbc425bab429a7f289f65f6
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08236819B2

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