Water → HCID 86601048, 화합물

HRID 883541노트

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HRID 883541 반응식
[NH2:1][C:2]1[N:7]([CH2:8][CH:9]([CH3:11])[CH3:10])[C:6](=[S:12])[NH:5][C:4](=[O:13])[CH:3]=1.[N:14]([O-])=[O:15].[Na+].O>C(O)(=O)C>[NH2:1][C:2]1[N:7]([CH2:8][CH:9]([CH3:11])[CH3:10])[C:6](=[S:12])[NH:5][C:4](=[O:13])[C:3]=1[N:14]=[O:15]

참가 물질

5

반응물 3

HCID 962WaterHCID 23668193Sodium NitriteHCID 866010496-Amino-1-isobutyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one

생성물 1

HCID 86601048HCID 86601048, 화합물수율 96.4%

시약·촉매·용매 1

HCID 176Acetic Acid용매

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온도
75 °C

실험 절차

6-Amino-1-isobutyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one (1.0 g, 5.0 mmol) was suspended in 10% acetic acid (20 mL). Sodium nitrite (0.38 g, 5.5 mmol) was added and the resulting mixture was heated at 75° C. for 1 h. The reaction mixture became first pink and then purple. The purple mixture was cooled to room temperature. Then water (20 mL) was added and the purple solid was collected by filtration and washed with water to give the title compound (1.1 g, 92% yield). This solid was used in the following step without further purification.

후처리

  1. temperatureThe purple mixture was cooled to room temperature
  2. filtrationthe purple solid was collected by filtration
  3. washwashed with water

출처 및 근거

ORD 기록
ord-8ee2ec76a5224efcb3b19d25b53f3da5
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08236951B2

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