Sodium Nitrite → HCID 86601058, 화합물

HRID 883555노트

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HRID 883555 반응식
[NH2:1][C:2]1[N:7]([CH2:8][CH:9]2[CH2:13][CH2:12][CH2:11][O:10]2)[C:6](=[S:14])[NH:5][C:4](=[O:15])[CH:3]=1.[N:16]([O-])=[O:17].[Na+]>C(O)(=O)C>[NH2:1][C:2]1[N:7]([CH2:8][CH:9]2[CH2:13][CH2:12][CH2:11][O:10]2)[C:6](=[S:14])[NH:5][C:4](=[O:15])[C:3]=1[N:16]=[O:17]

참가 물질

4

반응물 2

HCID 23668193Sodium NitriteHCID 252523746-Amino-2,3-dihydro-1-[(tetrahydro-2-furanyl)methyl]-2-thioxo-4(1H)-pyrimidinone

생성물 1

HCID 86601058HCID 86601058, 화합물수율 90.6%

시약·촉매·용매 1

HCID 176Acetic Acid용매

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온도
75 °C

실험 절차

6-Amino-1-(2-tetrahydrofuryl-methyl)-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one (1.3 g, 5.6 mmol) was suspended in 10% aqueous acetic acid (25 mL). Sodium nitrite (0.43 g, 6.2 mmol) was added and this mixture was heated at 75° C. for 1 h. The purple solid was collected by filtration, washed and dried, giving the title product (1.3 g, 90%).

후처리

  1. filtrationThe purple solid was collected by filtration
  2. washwashed
  3. customdried

출처 및 근거

ORD 기록
ord-9e591c55494f4109840b997130524381
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08236951B2

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