Dichloromethane → HCID 58017136, 화합물
반응식
[CH2:1]([O:3][C:4]([N:6]1[C:14]2[C:9](=[CH:10][C:11]([Cl:15])=[CH:12][CH:13]=2)[C:8]([CH2:21][C:22]([O:24]C(C)(C)C)=[O:23])([C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:7]1=[O:29])=[O:5])[CH3:2].ClCCl>>[Cl:15][C:11]1[CH:10]=[C:9]2[C:14](=[CH:13][CH:12]=1)[N:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[C:7](=[O:29])[C:8]2([CH2:21][C:22]([OH:24])=[O:23])[C:16]([O:18][CH2:19][CH3:20])=[O:17]참가 물질
3
실험 절차
To a solution of diethyl-3-(2-tert-butoxy-2-oxoethyl)-5-chloro-2-oxoindoline-1,3-dicarboxylate, intermediate 51, (1.83 g, 4.30 mmol) in dichloromethane (30 ml) trifluoroacetic acid (3.18 ml, 42.97 mmol) was added at 0-5° C. Stirring was continued at 0-5° C. for 30 minutes and at ambient temperature overnight. Evaporation and drying under high vacuum gave the title compound (1.57 g, 99%) as colorless oil (HPLC purity: 85%). MS (ESI+): 370.2
후처리
- customEvaporation
- customdrying under high vacuum
출처 및 근거
- ORD 기록
- ord-886036f70a364dd2ad3875a5eb919e01