4-Nitrobenzaldehyde → (3R,5S)-1-[(4-Nitrophenyl)methyl]-3,5-dimethylpiperazine

반응식

[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([CH:8]=O)=[CH:6][CH:5]=1)([O-:3])=[O:2].[CH3:12][C@@H:13]1[CH2:18][NH:17][CH2:16][C@H:15]([CH3:19])[NH:14]1>>[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([CH2:8][N:17]2[CH2:16][C@H:15]([CH3:19])[NH:14][C@H:13]([CH3:12])[CH2:18]2)=[CH:6][CH:5]=1)([O-:3])=[O:2]

참가 물질

반응물 2

HCID 5414-Nitrobenzaldehyde

HCID 6950261rel-(2R,6S)-2,6-dimethylpiperazine

생성물 1

HCID 59262210(3R,5S)-1-[(4-Nitrophenyl)methyl]-3,5-dimethylpiperazine

실험 절차

The title compound was prepared from 4-nitrobenzaldehyde and (2R,6S)-2,6-dimethylpiperazine using a method similar to that described for D21 in Description 21A. MS (ES): MH+ 250.2.

출처 및 근거

ORD 기록: ord-73ef899a68064cc9989b9d5bfba359ea
출처 데이터셋: uspto-grants-2012_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08236953B2

반응 노트

불러오는 중…