Methyl 2-(4-(benzyloxy)-3,5-dichlorophenylamino)benzoate → Methyl 2-(3,5-dichloro-4-hydroxyphenylamino)benzoate

HRID 883819

반응식

HRID 883819 반응식
C([O:8][C:9]1[C:14]([Cl:15])=[CH:13][C:12]([NH:16][C:17]2[CH:26]=[CH:25][CH:24]=[CH:23][C:18]=2[C:19]([O:21][CH3:22])=[O:20])=[CH:11][C:10]=1[Cl:27])C1C=CC=CC=1>[Pd].C1COCC1>[Cl:15][C:14]1[CH:13]=[C:12]([NH:16][C:17]2[CH:26]=[CH:25][CH:24]=[CH:23][C:18]=2[C:19]([O:21][CH3:22])=[O:20])[CH:11]=[C:10]([Cl:27])[C:9]=1[OH:8]

참가 물질

4

반응물 1

HCID 59509768Methyl 2-(4-(benzyloxy)-3,5-dichlorophenylamino)benzoate

생성물 1

HCID 59509759Methyl 2-(3,5-dichloro-4-hydroxyphenylamino)benzoate

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

Palladium on carbon (10% by mass of 10% by wt Pd, 50 mg) was cautiously added to a deoxygenated stirring solution of methyl 2-(4-(benzyloxy)-3,5-dichlorophenylamino)benzoate (0.520 g, 1.3 mmol) in THF (15 mL). The mixture was subjected to three cycles of evacuation and purging with hydrogen gas, before being stirred under an atmosphere of hydrogen gas. After 3 h, the reaction was purged with nitrogen, filtered through Celite™ (eluent: THF) and concentrated in vacuo to afford methyl 2-(3,5-dichloro-4-hydroxyphenylamino)benzoate as a white solid that was used without further purification.

후처리

  1. custompurging with hydrogen gas
  2. customthe reaction was purged with nitrogen
  3. filtrationfiltered through Celite™ (eluent: THF)
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-7bde8d590a624b9e8e29c4ca16a04b98
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08236984B2

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