반응식
[CH2:1]([C:3]1[N:8]=[C:7]([NH2:9])[CH:6]=[CH:5][CH:4]=1)[CH3:2].[CH2:10]([O:12][C:13](=[O:24])[C:14](=[CH:20]OCC)[C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH3:11]>>[CH2:10]([O:12][C:13](=[O:24])[C:14](=[CH:20][NH:9][C:7]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:1][CH3:2])[N:8]=1)[C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH3:11]참가 물질
3
반응 조건
- 온도
- 100 °C
실험 절차
The crude product from Example 8b was combined with 2-ethoxymethylene-malonic acid diethyl ester (6.6 mL, 0.032 mol) and the mixture heated under a N2 atmosphere in an oil bath at 100° C. for 2 h. Purified by flash chromatography on silica gel eluting with EtOAc/hexane giving the title compound (7.16 g, 98%).
후처리
- customPurified by flash chromatography on silica gel eluting with EtOAc/hexane giving the title compound (7.16 g, 98%)
출처 및 근거
- ORD 기록
- ord-eb849b1d0bbe4df2b73112607cc62a02
- 출처 데이터셋
- uspto-grants-2012_08
- 특허 번호
- US08236950B2
연결된 노트
불러오는 중…