Ammonia → 2-Amino-6-methylpyridine-3-carbonitrile

HRID 883855

반응식

HRID 883855 반응식
Cl[C:2]1[N:9]=[C:8]([CH3:10])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[NH3:11]>C(O)C>[NH2:11][C:2]1[N:9]=[C:8]([CH3:10])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 5204002-Chloro-6-methylpyridine-3-carbonitrile

생성물 1

HCID 130271112-Amino-6-methylpyridine-3-carbonitrile수율 82%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2-Chloro-6-methyl-nicotinonitrile (25 g, 0.164 mol) and liquid ammonia (250 mL) in 500 mL of ethanol were reacted in a sealed high-pressure vessel at 130° C. for 20 hours. The reaction mixture was concentrated under vacuum and the residue washed with water (2×50 mL) then dried in a vacuum oven for 24 hours to provide the title compound as a light yellow solid (18 g, 82%). 1H NMR (300 MHz, DMSO-d6) δ ppm: 2.30 (s, 3H), 6.52 (d, J=7.7 Hz, 1H), 6.78 (s, 2H), 7.73 (d, J=7.7 Hz, 1H).

후처리

  1. concentrationThe reaction mixture was concentrated under vacuum
  2. washthe residue washed with water (2×50 mL)
  3. customthen dried in a vacuum oven for 24 hours

출처 및 근거

ORD 기록
ord-f9f9ba3662e2455b876052fd6b8714be
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08236950B2

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