Methanol → 3-Amino-4-(4-methoxy-phenylsulfanyl)-benzoic acid methyl ester

HRID 883866노트

반응식

HRID 883866 반응식
[CH3:1][O:2][C:3](=[O:22])[C:4]1[CH:9]=[CH:8][C:7]([S:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=2)=[C:6]([N+:19]([O-])=O)[CH:5]=1.[Cl-].[NH4+].CO.O1CCCC1>[Fe].O>[CH3:1][O:2][C:3](=[O:22])[C:4]1[CH:9]=[CH:8][C:7]([S:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=2)=[C:6]([NH2:19])[CH:5]=1

참가 물질

7

반응물 4

HCID 887MethanolHCID 8028TetrahydrofuranHCID 25517Ammonium ChlorideHCID 41664294-(4-Methoxy-phenylsulfanyl)-3-nitro-benzoic acid methyl ester

생성물 1

HCID 613055833-Amino-4-(4-methoxy-phenylsulfanyl)-benzoic acid methyl ester수율 90%

시약·촉매·용매 2

HCID 23925Iron촉매HCID 962Water용매

실험 절차

To a solution of the product from Example 13A, iron powder and ammonium chloride in a methanol, tetrahydrofuran, and water solution was heated to reflux. The resultant mixture was filtered, and the filtrate was concentrated. Then ethyl acetate was added, stirred, filtered and concentrated to provide the title compound (7.16 g, 90%).

후처리

  1. filtrationThe resultant mixture was filtered
  2. concentrationthe filtrate was concentrated
  3. additionThen ethyl acetate was added
  4. filtrationfiltered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-b1f4d3b3ab3c4c358ded46292581f8db
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08236950B2

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