Ammonium Chloride → 3-Amino-4-(4-hydroxy-phenylsulfanyl)-phenol

HRID 883870노트

반응식

HRID 883870 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][C:10]=2[N+:16]([O-])=O)=[CH:4][CH:3]=1.[Cl-].[NH4+]>CCO.[Fe]>[NH2:16][C:10]1[CH:11]=[C:12]([OH:15])[CH:13]=[CH:14][C:9]=1[S:8][C:5]1[CH:6]=[CH:7][C:2]([OH:1])=[CH:3][CH:4]=1

참가 물질

5

반응물 2

HCID 25517Ammonium ChlorideHCID 670403614-(4-Hydroxy-phenylsulfanyl)-3-nitro-phenol

생성물 1

HCID 670403013-Amino-4-(4-hydroxy-phenylsulfanyl)-phenol수율 98.4%

시약·촉매·용매 2

HCID 23925Iron촉매HCID 702Ethanol용매

실험 절차

The product from Example 16A (1.34 g, 5.09 mmol) was reacted with iron (1.42 g, 25.48 mmol) and ammonium chloride (409 mg, 1.5 mmol) in 20 mL EtOH/20 mL THF/6 mL water following the procedure from Example 10E to provide the title compound (1.168 g, 97%).

출처 및 근거

ORD 기록
ord-52d5ccbf76434193a95310af8d387c25
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08236950B2

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