N'-(3-Cyano-pyridin-2-yl)-N,N-dimethyl-formamidine → 4-(4-Hydroxy-phenylsulfanyl)-3-(pyrido[2,3-d]pyrimidin-4-ylamino)-phenol

HRID 883871노트

반응식

HRID 883871 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([OH:16])[CH:5]=[CH:6][C:7]=1[S:8][C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=1.C([C:19]1[C:20]([N:25]=[CH:26][N:27]([CH3:29])C)=[N:21][CH:22]=[CH:23][CH:24]=1)#N.NC1C=C(OCC2C=CC=C(F)C=2)C=CC=1SC1C=CC(O)=CC=1>>[OH:15][C:12]1[CH:13]=[CH:14][C:9]([S:8][C:7]2[CH:6]=[CH:5][C:4]([OH:16])=[CH:3][C:2]=2[NH:1][C:29]2[C:19]3[CH:24]=[CH:23][CH:22]=[N:21][C:20]=3[N:25]=[CH:26][N:27]=2)=[CH:10][CH:11]=1

참가 물질

4

반응물 3

HCID 66808319N'-(3-Cyano-pyridin-2-yl)-N,N-dimethyl-formamidineHCID 668086774-[2-Amino-4-(3-fluoro-benzyloxy)-phenylsulfanyl]-phenolHCID 670403013-Amino-4-(4-hydroxy-phenylsulfanyl)-phenol2회

생성물 1

HCID 670407844-(4-Hydroxy-phenylsulfanyl)-3-(pyrido[2,3-d]pyrimidin-4-ylamino)-phenol수율 35.4%

실험 절차

The product of Example 16B (380 mg, 1.63 mmol) was reacted with the product of Example 15A (284 mg, 1.63 mmol) using the procedure of Example 15E substituting the product of Example 16B for the product of Example 15D to provide a solid which was triturated with methanol to provide the title compound (209 mg, 35%).

후처리

  1. customto provide a solid which
  2. customwas triturated with methanol

출처 및 근거

ORD 기록
ord-7d933d83cff84ce6b090c50c1425ffb0
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08236950B2

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