Dimethylformamide → 4-(4-Chloro-2-nitrophenoxy)benzoyl chloride

HRID 883897노트

반응식

HRID 883897 반응식
[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:15]=[CH:14][C:10]([C:11](O)=[O:12])=[CH:9][CH:8]=2)=[C:4]([N+:18]([O-:20])=[O:19])[CH:3]=1.C(Cl)(=O)C([Cl:24])=O.CN(C=O)C>C(Cl)Cl>[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:15]=[CH:14][C:10]([C:11]([Cl:24])=[O:12])=[CH:9][CH:8]=2)=[C:4]([N+:18]([O-:20])=[O:19])[CH:3]=1

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 24422524-(4-Chloro-2-nitrophenoxy)benzoic acid

생성물 1

HCID 866154944-(4-Chloro-2-nitrophenoxy)benzoyl chloride수율 100%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The product from Example 34b (4.0 g, 13.6 mmol) in 40 mL of CH2Cl2 was treated with oxalyl chloride (3.5 g, 27.2 mmol) and DMF (catalytic amount). Mixture was stirred for 12 hours. Mixture was concentrated under vacuum giving the title compound as a yellow oil (4.2 g, 100%).

후처리

  1. concentrationMixture was concentrated under vacuum

출처 및 근거

ORD 기록
ord-c6c9a97213114c2b8f1b4812f7127b26
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08236950B2

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