2-Methoxyethylamine → 4-(4-chloro-2-nitrophenoxy)-N-(2-methoxyethyl)benzamide

HRID 883898노트

반응식

HRID 883898 반응식
[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:15]=[CH:14][C:10]([C:11](Cl)=[O:12])=[CH:9][CH:8]=2)=[C:4]([N+:18]([O-:20])=[O:19])[CH:3]=1.[CH3:21][O:22][CH2:23][CH2:24][NH2:25]>C(Cl)Cl>[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:15]=[CH:14][C:10]([C:11]([NH:25][CH2:24][CH2:23][O:22][CH3:21])=[O:12])=[CH:9][CH:8]=2)=[C:4]([N+:18]([O-:20])=[O:19])[CH:3]=1

참가 물질

4

반응물 2

HCID 80182-MethoxyethylamineHCID 866154944-(4-Chloro-2-nitrophenoxy)benzoyl chloride

생성물 1

HCID 259313144-(4-chloro-2-nitrophenoxy)-N-(2-methoxyethyl)benzamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The compound from Example 34c (1.0 g, 3.2 mmol) in CH2Cl, was added to a mixture of 2-methoxyethanamine (722 mg, 9.61 mmol) in CH2Cl2. Mixture was stirred for 12 hours. Mixture was concentrated under vacuum giving the title compound, which was purified by silica gel column chromatography eluting with 50% EtOAc/hexane giving the title compound as a yellow oil (1.1 g, 100%).

후처리

  1. concentrationMixture was concentrated under vacuum

출처 및 근거

ORD 기록
ord-0eb19f933332488b99aa77dee45322bd
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08236950B2

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