Potassium Carbonate → HCID 66808423, 화합물

HRID 883921

반응식

HRID 883921 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8](Br)[CH3:9])=[CH:4][CH:3]=1.[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][C:13]=1[N+:19]([O-:21])=[O:20].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C.O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([O:18][C:15]2[CH:16]=[CH:17][C:12]([Cl:11])=[C:13]([N+:19]([O-:21])=[O:20])[CH:14]=2)[CH3:9])=[CH:4][CH:3]=1

참가 물질

6

반응물 3

HCID 11430Potassium CarbonateHCID 691274-Chloro-3-nitrophenolHCID 98381461-Bromo-4-(1-bromoethyl)benzene

생성물 1

HCID 66808423HCID 66808423, 화합물수율 92.2%

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

The product from Example 44A (995 mg, 3.77 mmol) was reacted with 4-chloro-3-nitro-phenol (650 mg, 3.77 mmol) in 15 mL of DMF with K2CO3 (10.4 g, 3.77 mmol) at 80° C. for 3 h. Cooled to room temperature and diluted with water. Extracted with CH2Cl2, washed four times with water. Dried over Na2SO4, filtered and concentrated under vacuum giving the title compound (1.24 g, 92%).

후처리

  1. extractionExtracted with CH2Cl2
  2. washwashed four times with water
  3. dry with materialDried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-01ea14048f1e47a8be43e546416167ed
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08236950B2

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