Ethyl Acetate → 2-Amino-2-methylpropyl di-tert-butyl phosphate
반응식
[C:1]([O:5][P:6]([O:13][CH2:14][C:15]([NH:18]C(=O)OCC1C=CC=CC=1)([CH3:17])[CH3:16])([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:7])([CH3:4])([CH3:3])[CH3:2].C(OCC)(=O)C.[H][H]>[OH-].[OH-].[Pd+2].CO>[P:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])([O:13][CH2:14][C:15]([NH2:18])([CH3:17])[CH3:16])=[O:7]참가 물질
6
실험 절차
The product of Example 95B (0.40 g, 0.96 mmol) and 20% palladium hydroxide on carbon (0.21 g) in a ethyl acetate (10 mL) and methanol (1 mL) was stirred under a an atmosphere of hydrogen for 0.5 hours. The reaction was filtered through a bed of celite and concentrate to give the title product (0.256 g).
후처리
- filtrationThe reaction was filtered through a bed of celite
- concentrationconcentrate
출처 및 근거
- ORD 기록
- ord-d2caa09872094c2db9006585af748727
- 출처 데이터셋
- uspto-grants-2012_08
- 특허 번호
- US08236950B2
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